Do you often reach for a cigarette or an e-cigarette when feeling anxious? Millions do, but what if nicotine was actually making your anxiety worse?
Nicotine is generally viewed by most as an anxiety fix-all, something that creates a temporary feeling of calm when life feels overwhelming. However, this temporary escape from tension and stress is deceptive.
While nicotine might feel reassuring in the short term, it tends to make anxiety disorders worse in the long term. The fact is, nicotine and anxiety are linked. Nicotine starts a pattern of dependence and withdrawal, which ends up affecting your mental health.
In this article, we answer the question, "Does nicotine cause anxiety?" using science-backed facts. Let's see why nicotine doesn't work as an anxiety reliever and how it actually causes more feelings of restlessness.
Everything You Need to Know About Nicotine and Anxiety
Smoking and Nicotine Cravings
For many smokers and vapers, nicotine cravings are common. During stressful days, it always seems like the simplest way to reduce anxiety is to vape or smoke. Nicotine, in fact, is known to possess an anxiolytic effect, which temporarily relieves stress.
The relationship between nicotine and anxiety is based on chemicals like dopamine. When nicotine enters your body, it affects your neural pathways. It triggers the release of dopamine, the neurotransmitter responsible for pleasure and reward. Nicotine use then leads to an immediate but not lasting relief. That temporary relief only masks the cause of anxiety, and when its effects subside, you end up more stressed.
The Negative Feedback Loop
Addiction to nicotine doesn't just happen overnight. This dependency creates a cycle that eventually affects your mental health. This is the negative feedback loop that makes you dependent on nicotine. It happens in this cycle:
- It Starts With Nicotine Dependence: The more you use nicotine, the more your body becomes dependent on it
- Increased Irritability and Anxiety as a Result of Nicotine Withdrawal: As soon as the nicotine is gone from your system, withdrawal symptoms like irritability become evident
- Reusing Nicotine to Get Temporary Relief: To get relief from the pangs of nicotine withdrawal, you grab a cigarette, vape, or e-cigarette, and you get another short-lived sense of calm
- Reinforcement of the Belief that Nicotine Relieves Anxiety: By doing this repeatedly, you reinforce the belief that nicotine keeps your anxiety at bay
This cycle isn’t limited to traditional cigarettes. E-cigarettes and vapes, too, perpetuate this cycle, despite being marketed as a healthier alternative. The feeling of calm that nicotine provides is only momentary, leaving you in a constant state of anxiety and withdrawal.
As you continue to use nicotine to relieve stress, your brain's natural ability to regulate mood becomes impaired. The more nicotine you consume, the more your body becomes dependent on it, leading to heightened anxiety symptoms during withdrawal.
While quitting smoking is difficult, there are healthier alternatives to manage nicotine cravings. For example, nicotine-free options such as Blakk Smoke's nicotine-free hookah vapes can help you enjoy a satisfying vaping experience without the damaging effects of nicotine and tobacco products.
The Neuroscience of Nicotine and the Anxious Brain
The Brain's Reward System
How does nicotine affect the brain? When you consume nicotine, it hijacks your brain's reward system. According to a study by Nguyen et al. (2021) in the journal Neurons, nicotine mimics acetylcholine, a neurotransmitter that helps regulate brain function in areas responsible for attention and relaxation. This mimicry triggers the release of dopamine, the brain’s "feel-good" chemical, giving you that brief sense of pleasure and relief from stress.
However, this effect comes with a price on your mental health. Over time, your brain becomes reliant on nicotine to trigger this release of dopamine, disrupting the natural balance of neurotransmitters. You start to crave nicotine to feel "normal," and without it, you're left feeling anxious, irritable, and more stressed than before. In some smokers, this increased anxiety might even lead to the development of panic disorders over time. More research suggests that panic and anxiety attacks may result in an increased risk of severe mental health disorders in genetically predisposed individuals (Nguyen et al., 2021).
Nicotine as a Stimulant
Nicotine is a stimulant, which means it speeds up bodily functions like heart rate and blood pressure. Nguyen et al. (2021) explain that these effects can mimic the physical symptoms of anxiety, such as a racing heart and increased muscle tension. Rather than easing your anxiety, nicotine actually increases it by artificially elevating your body's stress levels. Here’s how it works:
- Increased Heart Rate and Blood Pressure: Nicotine stimulates the release of adrenaline, which raises your heart rate and blood pressure. These physiological responses can also impact physical health in the long term.
- Anxiety-Like Behaviors: The stimulant properties of nicotine can contribute to jitteriness, restlessness, and irritability, all of which are commonly associated with anxiety disorders.
Nicotine’s Long-Term Impact on Mood Regulation
Smokefree, an initiative from the U.S. Department of Health and Human Services, notes that chronic nicotine use can significantly alter brain chemistry, particularly in areas that regulate mood. Over time, the brain's reward pathways become desensitized to dopamine, meaning you need more nicotine to achieve the same calming effect. This can lead to a variety of mood disturbances, like generalized anxiety disorder (GAD) and panic disorders.
Research from Smokefree suggests that chronic nicotine use can actually increase mental health problems like anxiety over time, even in the absence of withdrawal symptoms. This is because nicotine disrupts the brain's ability to manage stress effectively, leading to more frequent and intense anxiety episodes.

The True Impact of Quitting Smoking and Anxiety Disorders
The Nicotine Withdrawal Process
Quitting nicotine is no easy feat. When you stop using nicotine, both the physical and psychological symptoms of withdrawal can be intense. You might experience increased anxiety-like behaviors such as:
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Physical Effects:
- Muscle tension
- Increased appetite (often leading to weight gain)
- Trouble sleeping
- Muscle tension
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Psychological Effects:
- Irritability
- Anxiety
- Mood swings
- Depression
- Difficulty concentrating
- Irritability
These anxiety-like behaviors and symptoms of nicotine withdrawal can make quitting smoking feel like a constant battle, but they are temporary. They are signs that your body is adjusting to life without nicotine.
Short-Term Discomfort, Long-Term Relief
While nicotine withdrawal symptoms can be tough, this discomfort isn’t permanent. As your body and brain heal from nicotine and increased anxiety, you’ll start to notice significant improvements in your stress levels and overall symptoms.
Research suggests that after a few weeks of quitting smoking, many people may experience:
- A reduction in muscle tension
- Improved mood regulation
- Lowered levels of anxiety and stress
A study by Clendennen et al. (2023) in the Substance Use & Misuse journal suggests that people who stop smoking cigarettes or vaping report feeling less anxious and more relaxed after the nicotine withdrawal period passes. The point here is to push through the initial discomfort, knowing that the long-term benefits will far outweigh the short-term struggles.
More Research Findings on Quitting Smoking and Impacts on Anxiety
Clendennen et al. (2023) in Substance Use & Misuse highlight the mental health benefits of quitting smoking. They note that people who quit nicotine report:
- Reduced levels of generalized anxiety disorder (GAD)
- Lowered instances of panic attacks
- A more stable, positive mood overall
They also report that individuals who quit smoking for even just a few months experience significant improvement in their mental health, including a marked decrease in anxiety symptoms.
Note that when you stop smoking cigarettes, you allow your brain to return to a more balanced state, free from the cycles of nicotine addiction and withdrawal.
Quitting Strategies and Tools
Successfully quitting smoking often requires more than willpower. Fortunately, there are various tools and strategies available to help manage symptoms of nicotine withdrawal and improve your chances of success. These strategies include:
- Nicotine Replacement Therapy (NRT): Options like the nicotine patch or gum can help you gradually reduce nicotine intake.
- Therapy: Behavioral therapy and counseling can provide support in breaking addiction and learning healthier coping mechanisms.
- Support Groups: Surrounding yourself with others who are also quitting smoking can offer valuable motivation and accountability.
- Lifestyle Changes: Incorporating exercise, a healthy diet, and stress management techniques can help you handle nicotine withdrawal more effectively.
Important: Nicotine replacement therapies, like nicotine patches or lozenges, can also result in another form of addiction. This is because the addictive chemical, nicotine, is still present.
If you’re quitting smoking and looking for an alternative to nicotine, Blakk Smoke offers nicotine-free hookah pens made with real fruit juice. These can help you enjoy a satisfying experience without the cravings and anxiety that nicotine brings.
Actionable Tips for Managing Anxiety Without Nicotine
Mind-Body Connection
Managing your stress levels and anxiety without turning to nicotine starts with understanding the connection between your mind and body. Using healthy techniques can help you regain control over your stress levels and ease psychological symptoms naturally. Here are a few techniques that can help:
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Deep Breathing: This simple yet effective technique calms your nervous system by lowering your heart rate and reducing muscle tension.
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Mindfulness: Being present in the moment can help you detach from anxious thoughts and regain focus.
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Meditation: Practicing mindfulness or meditation for just a few minutes a day can reduce overall stress and anxiety.
Lifestyle Changes to Manage Anxiety
When quitting smoking, adjusting your daily habits can help you feel better physically and mentally. Making small changes to your lifestyle can reduce anxiety and promote overall well-being. Consider the following:
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Regular Physical Activity: Being physically active helps release endorphins, your body’s natural mood boosters. Thus, regular exercise can reduce stress and promote better sleep, which in turn alleviates anxiety.
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Dietary Adjustments: Reducing caffeine and alcohol can lower your stress levels. These substances can trigger or worsen symptoms of anxiety.
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Proper Sleep: Ensuring you get enough rest is important for your mental health. Poor sleep can heighten feelings of anxiety.
If you find yourself struggling with nicotine and anxiety, Blakk Smoke's mint hookah vapes could be a great option for relaxing and managing cravings without the increased anxiety-inducing effects of nicotine.

Frequently Asked Questions
Will Quitting Nicotine Help With Anxiety?
Yes, nicotine and anxiety are closely related. If you stop smoking cigarettes and choose to quit nicotine, you can reduce anxiety over time as your body adjusts and stabilizes without the stress of withdrawal symptoms. Many people report improved mood and less tension after quitting smoking.
Why Does Smoking Give Me Anxiety?
Tobacco products like cigarettes, e-cigarettes, or vapes contain nicotine, which has an anxiolytic effect. As such, smoking results in an increased risk of anxiety because nicotine stimulates your body’s stress response. It then raises your heart rate, mimicking anxiety symptoms.
Does Nicotine Cause Anxiety Attacks?
Yes. Studies suggest that nicotine can trigger anxiety attacks by increasing heart rate and stimulating the nervous system, resulting in panic-like symptoms (Nguyen et al., 2021). Other symptoms of nicotine withdrawal can also cause anxiety spikes.
Is Life Better Without Nicotine?
Life without nicotine improves overall health and reduces the physical and mental toll of addiction. You experience a more stable mood and a reduced state of anxiety. Many people feel more in control and less stressed.
Will You Be Happier If You Quit Smoking Nicotine?
Quitting nicotine often leads to increased happiness as it reduces anxiety and improves mood regulation over time. You’ll also experience more energy and a clearer mind after the nicotine withdrawal symptoms pass.
What Happens to Your Brain When You Quit Nicotine?
When you quit smoking, your brain begins to rebalance neurotransmitters like dopamine, improving mood and reducing anxiety and stress. Your brain recovers from addiction, and you start feeling more naturally relaxed.
Conclusion
Now you can comfortably answer the question, "Does nicotine cause anxiety?" At this point, it should be clear that nicotine doesn't alleviate anxiety in the long run. As your body becomes more reliant on it, the cycle of addiction and nicotine withdrawal amplifies physical and psychological symptoms of anxiety over time.
While quitting nicotine can be challenging, it's undoubtedly the best choice for your mental and physical health. When you break free from nicotine's grip, you open the door to a future where you manage anxiety without relying on substances that ultimately worsen your symptoms.
If you’re ready to take the first step toward quitting, remember that support is available. It doesn't matter if it's through nicotine replacement therapy or simply exploring healthier alternatives like Blakk Smoke's nicotine-free hookah pens; there are resources to help you along the way.
References
- Clendennen, S. L., Smith, J., Sumbe, A., Chen, B., Wilkinson, A. V., & Harrell, M. B. (2023). Symptoms of depression and anxiety, and subsequent use of nicotine and THC in electronic cigarettes. Substance Use & Misuse, 58(5), 591-600.
- Nguyen, C., Mondoloni, S., Le Borgne, T., Centeno, I., Come, M., Jehl, J., ... & Faure, P. (2021). Nicotine inhibits the VTA-to-amygdala dopamine pathway to promote anxiety. Neuron, 109(16), 2604-2615.
- Smokefree. (n.d.). Anxiety and smoking. Smokefree, U.S. Department of Health and Human Services.
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